Single-molecule confinement with uniform electrodynamic nanofluidics

Nanofluidics of Single-Crystal Diamond Nanomechanical Resonators.

Single-crystal diamond nanomechanical resonators are being developed for countless applications. A number of these applications require that the resonator be operated in a fluid, that is, a gas or a liquid. Here, we investigate the fluid dynamics of single-crystal diamond nanomechanical resonators in the form of nanocantilevers. First, we measure the pressure-dependent dissipation of diamond na...

Detection of confinement and jumps in single-molecule membrane trajectories.

We propose a variant of the algorithm by [R. Simson, E. D. Sheets, and K. Jacobson, Biophys. 69, 989 (1995)]. Their algorithm was developed to detect transient confinement zones in experimental single-particle tracking trajectories of diffusing membrane proteins or lipids. We show that our algorithm is able to detect confinement in a wider class of confining potential shapes than that of Simson...

Fabrication and Characterization of Nanofluidics Device Using Fused Silica for Single Protein Molecule Detection

Fabrication of nanofluidic devices was carried out and the devices were characterized. These devices will be used to trap, manipulate and detect single protein molecules in nanometer size channels in a laser fluorescence spectroscopy process to investigate dynamical and photophysical behavior of single molecules. On the substrate of fused silica (SiO2) glass wafers, Electron Beam Lithography (E...

Nanofluidics.

It is a pleasure to present this special issue on nanofluidics. Spurred by rapid technological advances in micromachining techniques, the research field of nanofluidics appeared about ten years ago. Nanofluidics is generally defined as the study of liquid flow in and around objects of 100 nm and less, and the applications thereof. Of course fluid research on this scale had already been studied ...

Analysing Approximate Confinement under Uniform Attacks